Contacts
sdbain@u.washington.edu
P: 206.897.5601
F: 206.897.5611
Education
Post-Doc SUNY Stony Brook - Musculoskeletal Research (1990)
Ph.D. Washington State University - Veterinary Science (1987)
B.S. Northern Arizona University - Biology Education (1977)
Research Interests
Research interests include the neuronal control of bone homeostasis, the effects of physical stimuli on fracture repair and tissue regeneration, and the neuromuscular signaling pathways that mediate the formation of heterotopic bone.
Current Academic Appointments
Research Associate Professor
Department of Orthopaedics and Sports Medicine, University of Washington (2008 to Present)
Honors
NASA Space Biology Research Fellow (1988-90)
Graduate and Professional Student Competitive Travel Grant Award (1987)
Arturs Vitums Endowed Scholarship in Veterinary Anatomy (1987)
Pacific Egg and Poultry Association Research Scholarship (1987)
Poultry Science Association Certificate of Excellence Award (1987)
Recent Publications
1. Bain, SD, P Huber, BJ Ausk, RY Kwon, EM Gardiner, S Srinivasan, TS Gross, 2019. Neuromuscular dysfunction, independent of gait dysfunction, modulates trabecular bone homeostasis in mice. J Musculoskelet Neuronal Interact, 19(1):79-93.
2. Srinivasan, S, SD Bain, BJ Ausk, TS Gross, 2018. Static Preload Inhibits Loading Induced Bone Formation. J Bone Min Res Plus, DOI:10.1002/jbm4.10087
3. Worton, LE, EM Gardiner, S Srinivasan, RY Kwon, LM Downey, BJ Ausk, SD Bain, TS Gross, 2018. Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression. PLoS One. 13(11): e0207354.
4. Ausk, BJ, LE Worton, KS Smigiel, RY Kwon, SD Bain, S Srinivasan, EM Gardiner, TS Gross, 2017. Muscle Paralysis Induces Bone Marrow Inflammation and Predisposition to Form Giant Osteoclasts. Am J Physiol Cell Physiol. 313(5):C533-C540.
5. Pagnotti, GM, ME Chan, BJ Adler, KR Shroyer, J Rubin, SD Bain, CT Rubin, 2016. Low Intensity Vibration Mitigates Tumor Progression and Protects Bone Quantity and Quality in a Murine Model of Myeloma. Bone. 90:69-79.
6. Ausk, BJ, TS Gross, SD Bain, 2015. Botulinum Toxin Induced Muscle Paralysis Inhibits Heterotopic Bone Formation. Clin. Ortho. Rel. Res. 473(9):2825-2830.
7. Srinivasan, S, BJ Ausk, SD Bain, EM Gardiner, RY Kwon, TS Gross, 2015. Rest-intervals Reduce the Number of Loading Bouts Required to Enhance Periosteal Bone Formation. Med Sci Sports and Exercise. 47(5):1095-1103.
8. Recidoro, AM, AC Roof, M Schmitt, T Petrie, N Strand, BJ Ausk, S Srinivasan, EM Gardiner, W Kaminsky, SD Bain, CH Allan, TS Gross, RY Kwon, 2014. Botulinum Toxin Induces Muscle Paralysis and Inhibits Bone Regeneration in Zebrafish. J Bone Min Res. 29(11):2346-2356.
9. Worton LE, BJ Ausk, LM Downey, SD Bain, EM Gardiner, S Srinivasan, TS Gross, RY Kwon, 2013. Systems-based identification of temporal processing pathways during bone cell mechanotransduction. PloS one. 2013; 8(9):e74205.
10. Srinivasan, S, D Threet, LE Worton, BJ Ausk, SD Bain, EM Gardiner; RY Kwon; TS Gross, 2013. Distinct Cyclosporin A Supplements are Required to Enhance Bone Formation Induced by Cyclic and Rest-Inserted Loading in the Senescent Skeleton. PLOS One. 9(1):e84868.
11. Ausk, BJ, P Huber, S Srinivasan, SD Bain, RY Kwon, EA McNamara, SL Poliachik, CL Sybrowsky, TS Gross, 2013. Metaphyseal and diaphyseal bone loss in the tibia following transient muscle paralysis are spatiotemporally distinct resorption events. Bone. 57(2):413-422.
12. Yang, L, J Zou, J Hacquebord, KA Lawson, D Patterson, AC Ghatan, Q Mei, A Zielinska- Kwiatkowski, SD Bain, RJ Fernandes, HA Chansky, HA, 2013. ESET histone methyltransferase is essential to hypertrophic differentiation of chondrocytes and formation of epiphyseal plates. Developmental Biology. 380(1):99-110.
13. Srinivasan, S, SD Bain, TS Gross, 2012. Bone Mechanotransduction May Require Augmentation in Order to Strengthen the Senescent Skeleton. Ageing Research Reviews. 11(3):353-60.
