Contact
lworton@uw.edu
P: 206.604.1553
F: 206.897.5611
Education
Ph.D. University of Queensland, Brisbane, Australia - Medicine (2009)
B.S.c University of Sydney, Australia – Molecular Biology and Genetics (2001)
Research Interests
My current research investigates cell signaling responses to mechanical stimuli in osteoblastic cells, particularly with a focus on how these responses change with aging.
Current Academic Appointments
Senior Research Fellow
Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington (2009 to Present)
Honors
Diamantina Institute PhD Travel Award (2007)
ASBMR Young Investigator Travel Grant (2007)
ANZBMS Travel Award (2007)
ANZ Trustees PhD Scholarship in Medical Research, QLD (2006)
IOF/ANZBMS Travel Award (2006)
University of Queensland Joint Research Scholarship (2005)
Australian Postgraduate Award (2004)
UNSW Faculty of Medicine Rising Star Award (2004)
Professor Spencer Smith-White Prize in Biology Honours (2001)
Recent Publications
- Bain SD, Huber P, Ausk BJ, Kwon RY, Gardiner EM, Srinivasan S, Gross TS. Neuromuscular dysfunction, independent of gait dysfunction, modulates trabecular bone homeostasis in mice. J Musculoskelet Neuronal Interact. 2019 Mar;19(1):79-93. PubMed PMID: 30839306; PubMed Central PMCID: PMC6454260.
- Worton LE, Gardiner EM, Kwon RY, Downey LM, Ausk BJ, Bain SD, Gross TS. Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression. PLoS One. 2018;13(11):e0207354. doi: 10.1371/journal.pone.0207354. eCollection 2018. PubMed PMID: 30427927; PubMed Central PMCID: PMC6235354.
- Ausk BJ, Worton LE, Smigiel KS, Kwon RY, Bain SD, Srinivasan S, Gardiner EM, Gross TS. Muscle paralysis induces bone marrow inflammation and predisposition to formation of giant osteoclasts. Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C533-C540. doi: 10.1152/ajpcell.00363.2016. Epub 2017 Aug 30. PubMed PMID: 28855162; PubMed Central PMCID: PMC5792168.
- Worton LE, Shi YC, Smith EJ, Barry SC, Gonda TJ, Whitehead JP, Gardiner EM. Ectodermal-Neural Cortex 1 Isoforms Have Contrasting Effects on MC3T3-E1 Osteoblast Mineralization and Gene Expression. J Cell Biochem. 2017 Aug;118(8):2141-2150. doi: 10.1002/jcb.25851. Epub 2017 Apr 18. PubMed PMID: 27996212.
- Recidoro AM, Roof AC, Schmitt M, Worton LE, Petrie T, Strand N, Ausk BJ, Srinivasan S, Moon RT, Gardiner EM, Kaminsky W, Bain SD, Allan CH, Gross TS, Kwon RY. Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish. J Bone Miner Res. 2014 Nov;29(11):2346-56. doi: 10.1002/jbmr.2274. PubMed PMID: 24806738; PubMed Central PMCID: PMC5108653.
- Worton LE, Kwon RY, Gardiner EM, Gross TS, Srinivasan S. Enhancement of Flow-Induced AP-1 Gene Expression by Cyclosporin A Requires NFAT-Independent Signaling in Bone Cells. Cell Mol Bioeng. 2014 Jun 1;7(2):254-265. doi: 10.1007/s12195-014-0321-3. PubMed PMID: 25484988; PubMed Central PMCID: PMC4255985.
- Srinivasan S, Threet D, Worton LE, Ausk BJ, Bain SD, Gardiner EM, Kwon RY, Gross TS. Distinct cyclosporin a doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton. PLoS One.2014;9(1):e84868. doi: 10.1371/journal.pone.0084868. eCollection 2014. PubMed PMID: 24404194; PubMed Central PMCID: PMC3880323.
- Worton LE, Ausk BJ, Downey LM, Bain SD, Gardiner EM, Srinivasan S, Gross TS, Kwon RY. Systems-based identification of temporal processing pathways during bone cell mechanotransduction. PLoS One. 2013;8(9):e74205. doi: 10.1371/journal.pone.0074205. eCollection 2013. PubMed PMID: 24040202; PubMed Central PMCID: PMC3770665.
