Brandon J. Ausk, Ph.D.


P: 206.897.5610
F: 206.897.5611 


Ph.D. University of Washington - Bioengineering (2013)
M.S. University of Washington - Mechanical Engineering (2004)
B.S. Montana State University - Mechanical Engineering (2002)

Research Interests

Research interests include translational research for prophylactic inhibition of heterotopic ossification, neuromuscular control of bone homeostasis, and modeling of bone mechanotransduction.  

Current Academic Appointments

Research Engineer/Research Scientist
Department of Orthopaedics and Sports Medicine, University of Washington (2004 to Present)​


National Institute on Aging: Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (2010 to 2012)
ASBMR Young Investigator Travel Grant Recipient (2007)
Mechanical Engineering Teaching Assistantship, Mechanical Engineering University of Washington (2002-03)
Graduate with Highest Honors- Mechanical Engineering, Montana State University (2002)
Pi Tau Sigma Mechanical Engineering Honor Society (2002)
Montana State Alumni Award of Excellence (2002)
Mechanical Engineering Senior Design Scholarship, Montana State University (2002)
Montana State University Alumni Association Scholarship (2001)
Mechanical Engineering Scholarship – Montana State University (2001)

Recent Publications

  1. Srinivasan S, Balsiger D, Huber P, Ausk BJ, Bain SD, Gardiner EM, Gross TS. Static Preload Inhibits Loading-Induced Bone Formation. JBMR Plus. 2019 May;3(5):e10087. doi: 10.1002/jbm4.10087. eCollection 2019 May. PubMed PMID: 31131340; PubMed Central PMCID: PMC6524670. 
  2. Bain SD, Huber P, Ausk BJ, Kwon RY, Gardiner EM, Srinivasan S, Gross TS. Neuromuscular dysfunction, independent of gait dysfunction, modulates trabecular bone homeostasis in mice. J Musculoskelet Neuronal Interact. 2019 Mar 1;19(1):79-93. PubMed PMID: 30839306; PubMed Central PMCID: PMC6454260. 
  3. Worton LE, Gardiner EM, Kwon RY, Downey LM, Ausk BJ, Bain SD, Gross TS. Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression. PLoS One. 2018;13(11):e0207354. doi: 10.1371/journal.pone.0207354. eCollection 2018. PubMed PMID: 30427927; PubMed Central PMCID: PMC6235354. 
  4. Ausk BJ, Worton LE, Smigiel KS, Kwon RY, Bain SD, Srinivasan S, Gardiner EM, Gross TS. Muscle paralysis induces bone marrow inflammation and predisposition to formation of giant osteoclasts. Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C533-C540. doi: 10.1152/ajpcell.00363.2016. Epub 2017 Aug 30. PubMed PMID: 28855162; PubMed Central PMCID: PMC5792168. 
  5. Ausk BJ, Gross TS, Bain SD. Botulinum Toxin-induced Muscle Paralysis Inhibits Heterotopic Bone Formation. Clin Orthop Relat Res. 2015 Sep;473(9):2825-30. doi: 10.1007/s11999-015-4271-4. PubMed PMID: 25804882; PubMed Central PMCID: PMC4523519. 
  6. Srinivasan S, Ausk BJ, Bain SD, Gardiner EM, Kwon RY, Gross TS. Rest intervals reduce the number of loading bouts required to enhance bone formation. Med Sci Sports Exerc. 2015 May;47(5):1095-103. doi: 10.1249/MSS.0000000000000509. PubMed PMID: 25207932; PubMed Central PMCID: PMC4368504. 
  7. Recidoro AM, Roof AC, Schmitt M, Worton LE, Petrie T, Strand N, Ausk BJ, Srinivasan S, Moon RT, Gardiner EM, Kaminsky W, Bain SD, Allan CH, Gross TS, Kwon RY. Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish. J Bone Miner Res. 2014 Nov;29(11):2346-56. doi: 10.1002/jbmr.2274. PubMed PMID: 24806738; PubMed Central PMCID: PMC5108653. 
  8. Srinivasan S, Threet D, Worton LE, Ausk BJ, Bain SD, Gardiner EM, Kwon RY, Gross TS. Distinct cyclosporin a doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton. PLoS One.2014;9(1):e84868. doi: 10.1371/journal.pone.0084868. eCollection 2014. PubMed PMID: 24404194; PubMed Central PMCID: PMC3880323. 
  9. Ausk BJ, Huber P, Srinivasan S, Bain SD, Kwon RY, McNamara EA, Poliachik SL, Sybrowsky CL, Gross TS. Metaphyseal and diaphyseal bone loss in the tibia following transient muscle paralysis are spatiotemporally distinct resorption events.Bone. 2013 Dec;57(2):413-22. doi: 10.1016/j.bone.2013.09.009. Epub 2013 Sep 21. PubMed PMID: 24063948; PubMed Central PMCID: PMC3865853. 
  10. Worton LE, Ausk BJ, Downey LM, Bain SD, Gardiner EM, Srinivasan S, Gross TS, Kwon RY. Systems-based identification of temporal processing pathways during bone cell mechanotransduction. PLoS One. 2013;8(9):e74205. doi: 10.1371/journal.pone.0074205. eCollection 2013. PubMed PMID: 24040202; PubMed Central PMCID: PMC3770665. 
  11. Ausk BJ, Huber P, Poliachik SL, Bain SD, Srinivasan S, Gross TS. Cortical bone resorption following muscle paralysis is spatially heterogeneous. Bone. 2012 Jan;50(1):14-22. doi: 10.1016/j.bone.2011.08.028. Epub 2011 Sep 5. PubMed PMID: 21920486; PubMed Central PMCID: PMC3243779.