Edith M. Gardiner, Ph.D.

Edith Gardiner     




Post-Doc Garvan Institute of Medical Research, Australia -- Bone biology (1993)
Post-Doc Yale University Biology Department -- Oncogenes (1989)
Ph.D. Yale University School of Medicine -- Human Genetics (1988)
B.S. Duke University -- Biology (1977)

Research Interests

Research interests include sympathetic control of the osteoblastic lineage, the importance of autonomic dysfunction in age-related bone loss, the cellular and molecular mechanisms of bone anabolism and response to mechanical stimulation.

Current Academic Appointments

Research Associate Professor
Department of Orthopaedics and Sports Medicine, University of Washington (20014 to Present)


Editorial Board, Endocrinology -- 2009-12    
Editorial Board, Journal of Bone and Mineral Research -- 2004-09    
Hull Award, Yale Comprehensive Cancer Center, Yale University -- 1991, 1992

Recent Publications

  1. Worton LE, Srinivasan S, Threet D, Ausk BJ, Huber P, Kwon RY, Bain SD, Gross TS, Gardiner EM. Beta 2 Adrenergic receptor selective antagonist enhances mechanically stimulated bone anabolism in aged mice. JBMR Plus 2002, 7(2):e10712. PMID: 36751418
  2. Watson CJ, Tang WJ, Fiedler IAK, Rojas MF, Montes de Oca EM, Cronrath AR, Callies LK, Swearer AA, Ahmed AR, Sethuraman V, Addish S, Farr III GH, Gomez AE, Rai J, Monstad-Rios AT, Gardiner EM, Karasik D, Maves L, Busse B, Hsu HY, Kwon RY Wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. Plos Genetics 2022, 18(11):e1010496. PMID: 363468
  3. Bain SD, Huber P, Ausk BJ, Kwon RY, Gardiner EM, Srinivasan S, Gross TS. Neuromuscular dysfunction, independent of gait dysfunction, modulates trabecular bone homeostasis in mice. J Musculoskelet Neuronal Interact. 2019. 19: 79-93. PMID: 30839306
  4. Srinivasan S, Balsiger D, Huber P, Ausk BJ, Bain SD, Gardiner EM, Gross TS. Static preload inhibits loading-induced bone formation. JBMR Plus 2019. 3(5):e10087. PMID 31131340
  5. Worton LE, Gardiner EM, Kwon RY, Downey LM, Ausk BJ, Bain SD, Gross TS. Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression. PLoS One. 2018;13(11):e0207354. doi: 10.1371/journal.pone.0207354. eCollection 2018. PubMed PMID: 30427927; PubMed Central PMCID: PMC6235354. 
  6. Ausk BJ, Worton LE, Smigiel KS, Kwon RY, Bain SD, Srinivasan S, Gardiner EM, Gross TS. Muscle paralysis induces bone marrow inflammation and predisposition to formation of giant osteoclasts. Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C533-C540. doi: 10.1152/ajpcell.00363.2016. Epub 2017 Aug 30. PubMed PMID: 28855162; PubMed Central PMCID: PMC5792168. 
  7. Worton LE, Shi YC, Smith EJ, Barry SC, Gonda TJ, Whitehead JP, Gardiner EM. Ectodermal-Neural Cortex 1 Isoforms Have Contrasting Effects on MC3T3-E1 Osteoblast Mineralization and Gene Expression. J Cell Biochem. 2017 Aug;118(8):2141-2150. doi: 10.1002/jcb.25851. Epub 2017 Apr 18. PubMed PMID: 27996212. 
  8. Srinivasan S, Ausk BJ, Bain SD, Gardiner EM, Kwon RY, Gross TS. Rest intervals reduce the number of loading bouts required to enhance bone formation. Med Sci Sports Exerc. 2015 May;47(5):1095-103. doi: 10.1249/MSS.0000000000000509. PubMed PMID: 25207932; PubMed Central PMCID: PMC4368504. 
  9. Recidoro AM, Roof AC, Schmitt M, Worton LE, Petrie T, Strand N, Ausk BJ, Srinivasan S, Moon RT, Gardiner EM, Kaminsky W, Bain SD, Allan CH, Gross TS, Kwon RY. Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish. J Bone Miner Res. 2014 Nov;29(11):2346-56. doi: 10.1002/jbmr.2274. PubMed PMID: 24806738; PubMed Central PMCID: PMC5108653. 
  10. Worton LE, Kwon RY, Gardiner EM, Gross TS, Srinivasan S. Enhancement of Flow-Induced AP-1 Gene Expression by Cyclosporin A Requires NFAT-Independent Signaling in Bone Cells. Cell Mol Bioeng. 2014 Jun 1;7(2):254-265. doi: 10.1007/s12195-014-0321-3. PubMed PMID: 25484988; PubMed Central PMCID: PMC4255985. 
  11. Vela I, Morrissey C, Zhang X, Chen S, Corey E, Strutton GM, Nelson CC, Nicol DL, Clements JA, Gardiner EM. PITX2 and non-canonical Wnt pathway interaction in metastatic prostate cancer. Clin Exp Metastasis. 2014 Feb;31(2):199-211. doi: 10.1007/s10585-013-9620-7. Epub 2013 Oct 26. PubMed PMID: 24162257. 
  12. Srinivasan S, Threet D, Worton LE, Ausk BJ, Bain SD, Gardiner EM, Kwon RY, Gross TS. Distinct cyclosporin a doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton. PLoS One.2014;9(1):e84868. doi: 10.1371/journal.pone.0084868. eCollection 2014. PubMed PMID: 24404194; PubMed Central PMCID: PMC3880323. 
  13. Worton LE, Ausk BJ, Downey LM, Bain SD, Gardiner EM, Srinivasan S, Gross TS, Kwon RY. Systems-based identification of temporal processing pathways during bone cell mechanotransduction. PLoS One. 2013;8(9):e74205. doi: 10.1371/journal.pone.0074205. eCollection 2013. PubMed PMID: 24040202; PubMed Central PMCID: PMC3770665.