Introduction to the OSL
The Orthopaedic Science Laboratories (OSL) broadly examines how bone responds to physical stimuli, both small and large. We use multi-disciplinary approaches to examine basic cellular signaling pathways at levels ranging from gene expression changes in response to mechanical loading (or lack thereof) to use of complex adaptive systems biology to study the integrated behaviors of osteocyte/osteoblast networks. We are currently focused on exploring how neuroskeletal interactions modulate bone adaptation and regeneration.
Recent or Upcoming OSL Presentations
2019 41st American Society of Bone and Mineral Research Annual Meeting
Gross, T.S., Gardiner, E.M., Worton, L.E., Ausk, B.J., Bain, S.D., Shubin, N., Piliponsky, A. (2019) Mast cell deficiency partially mitigates acute bone resorption following muscle paralysis. 2019 ASBMR
International Society of Biomechanics 2019 Congress
Tucker, A.M., Gross, T.S., Cizik, A.M., Srinivasan, S., Ausk, B.J. (2019) The effect of static preload on bone anabolism: a systematic review and meta-analysis. International Society of Biomechanics 2019 Congress
Gross, T.S., Bain, S.D., Srinivasan, S. (2019) Translating exogenous loading studies to clinical interventions. International Society of Biomechanics 2019 Congress
2018 40th American Society of Bone and Mineral Research Annual Meeting
Gardiner, E.M., Srinivasan, S., Threet, D., Huber, P., Ausk, B.J., Worton, L, Kwon, R.Y., Bain, S.D., Gross, T.S. (2018) Beta 2 adrenergic receptor gene deletion enhances periosteal response to mechanical stimulation in senescent male mice (2018). 2018 ASBMR
Srinivasan, S., Threet, D., Huber, P, Gross, T.S., Bain, S.D., Gardiner, E.M. (2018) Cyclosporin A enhances loading induced trabecular and cortical formation at senscence. 2018 ASBMR
Srinivasan, S., Ausk, B.J., Gross, T.S. (2018) Cyclosporine A dose specifically enhances bone adaptation in the trabecular and cortical bone compartments, 2018 ASBMR
