Matthew Thompson, M.D.

Assistant Professor

University of Kansas
Medical School
University of Kansas School of Medicine
Virginia Commonwealth University Medical Center
University of Washington
Board Certification

Dr. Thompson is an assistant professor in the Department of Orthopaedics and Sports Medicine. He is an orthopaedic oncologist specializing in the surgical management of tumors of the extremities and pelvis, with a primary focus on sarcoma and complex limb reconstruction. He practices at the Seattle Cancer Care Alliance, Seattle Children’s Hospital, and University of Washington Medical Center.

Dr. Thompson is a published author and reviews for both national and international scientific journals. His clinical research focuses on the management of benign, malignant, and metastatic tumors of the musculoskeletal system. He is currently collaborating on projects that will assess the utility of fluorescence-guided surgery in orthopaedic oncology and to develop new technologies in this area. He is also interested in optimizing provider-to-provider communication and in assessing the effects of cognitive bias on simulated patient decision-making in orthopaedic oncology. He is interested in studying the comprehensive treatment of avascular necrosis of bone in adults and children and in future applications of computer-assisted surgery.

Dr. Thompson studied biochemistry at the University of Kansas prior to attending the University of Kansas School of Medicine where he was honored with the Best Student Recognition of Achievement in Foundations of Medicine and was inducted into the Alpha Omega Alpha Honor Society. He completed residency in orthopaedic surgery at Virginia Commonwealth University Medical Center where he was nominated to the Resident Leadership Forum of the American Orthopaedic Association and was the recipient of the Award for Excellence for Outstanding Achievement and Contribution to the Orthopaedic Residency Program. He then completed specialized fellowship training in orthopaedic oncology at the University of Washington.

Dr. Thompson is recognized as an Emerging Leader by the American Orthopaedic Association and is a current member of the Connective Tissue Oncology Society, Musculoskeletal Tumor Society (candidate), American Academy of Orthopaedic Surgeons (candidate), Fred Hutchinson/University of Washington Cancer Consortium, Seattle Translational Tumor Research, and the American Medical Association.

Patient Care Philosophy

"I believe that patient-centered treatment is best achieved through shared decision-making with my patient, his or her family, and a team of collaborative providers. I am dedicated to ensuring that an informed patient is able to guide his or her care in accordance with his or her unique experience and wishes. My most influential mentors sought first to always understand the disease in the context of the person."

Clinical Interests
  • Sarcoma
  • Benign, malignant, and metastatic tumors of the musculoskeletal system
  • Pathologic fractures
  • Complex reconstruction of the extremities and pelvis
  • Avascular necrosis of bone
  • Revision arthroplasty
Personal Interests

"I enjoy spending time with my beautiful and compassionate wife, adorable young daughters, and a pair of misbehaving dachshunds. Together, we enjoy traveling, camping, hiking, skiing, eating good food, and exploring new scenery. My other interests include the challenge and serenity of piloting small aircraft, woodworking, clearing my head on the driving range… despite minimal tangible improvement in my game, and generally learning new things."

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Improved accuracy and precision of orthopaedic oncologic surgery and limb reconstruction through economical fabrication of 3D printed instruments locally.

  • Creation of 3-dimensional models of a patient's disease in preparation for and/or simulation of surgery.
  • Creation of 3D-printed surgical instruments ("cutting guide") customized to facilitate a particular patient's surgery.

Fluorescence-guided surgery in Sarcoma (use of fluorescent molecules to illuminate cancer cells, distinguishing them from normal tissue)

  • Collaboration exploring applications of fluorescence-guided surgery in soft tissue sarcoma.
  • Collaboration with basic scientists exploring novel technologies and tools to facilitate fluorescence guided surgery.

Optimizing patient-provider partnership in Orthopaedic Oncology

  • Exploring effects of geographic distance from the treatment center on patient experience and outcomes. Assessing potential applications of telemedicine, patient-tracking applications, step counters and other tools that improve patient and provider satisfaction.
  • Exploring risk calculators/nomograms to facilitate decision making in the surgical treatment of soft tissue sarcoma.
  • Exploring studies related to early outcomes following treatment of metastatic disease.
  • Recent publication assessing whether a virtual patient's choice between limb salvage or amputation could be affected by the way relevant information is presented to the patient.
  • Recent publication reviewing the modern approach to patient-centered and disease-specific care of patients with skeletal metastatic disease.

Selected Recent Publications:

  1. Extra-articular Hip Resection and Reconstruction with Custom Acetabular Resection Guide and Implants in a Case of High-Grade Spindle Cell Sarcoma of the Proximal Femur. A Case Report. JBJS Case Connector. 2020
  2. Impact of Nodal Involvement on Survival Outcomes in Chondrosarcoma: Retrospective Cohort Analysis of Surveillance, Epidemiology, and End Results (SEER) Database (2004-2015). Int J Surg Oncol. 2020
  3. Bone Health After Hematopoietic Cell Transplantation: An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy. Biol Blood Marrow Transplant. 2020.
  4. Multiplexed Evaluation of microdosed antineoplastic agents in situ in the tumor microenvironment of patients with soft tissue sarcoma. Clin Cancer Res. 2020
  5. Decision-making in Orthopaedic Oncology – Does Cognitive Bias Affect a Virtual Patient’s Choice Between Limb Salvage and Amputation? Clin Orthop Relat Res. 2019
  6. Contemporary Management of Appendicular Skeletal Metastasis by Primary Tumor Type. J Am Acad Orthop Surg. 2018
  7. MRI Identification of the Osseous Extent of Pediatric Bone Sarcomas. Clin Orthop Relat Res. 2018
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